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KMID : 0923620230230040031
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Immune Network
2023 Volume.23 No. 4 p.31 ~ p.31
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A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections
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Francislaine Aparecida dos Reis Livero
Lee Yoo-Jin
You Jin-Sun
Hwang Won-Tae
Hwang Jee-Won
Beverly Spray
Kim Ji-Eun
Jo A-Ra
Park In-Ho
Mohammed Ali
Kim Jong-Sun
Shin Jeon-Soo
Kwon Ho-Keun
Kim Hyun-Jik
Yoon Sang-Sun
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Abstract
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Evidence suggests that the human respiratory tract, as with the gastrointestinal tract, has evolved to its current state in association with commensal microbes. However, little is known about how the airway microbiome affects the development of airway immune system. Here, we uncover a previously unidentified mode of interaction between host airway immunity and a unique strain (AIT01) of Staphylococcus epidermidis, a predominant species of the nasal microbiome. Intranasal administration of AIT01 increased the population of neutrophils and monocytes in mouse lungs. The recruitment of these immune cells resulted in the protection of the murine host against infection by Pseudomonas aeruginosa, a pathogenic bacterium. Interestingly, an AIT01-secreted protein identified as GAPDH, a well-known bacterial moonlighting protein, mediated this protective effect. Intranasal delivery of the purified GAPDH conferred significant resistance against other Gram-negative pathogens (Klebsiella pneumoniae and Acinetobacter baumannii) and influenza A virus. Our findings demonstrate the potential of a native nasal microbe and its secretory protein to enhance innate immune defense against airway infections. These results offer a promising preventive measure, particularly relevant in the context of global pandemics.
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KEYWORD
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Staphylococcus epidermidis, Human nasal microbiome, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Innate immune defense
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